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Iron-Catalyzed Direct Diazidation for a Broad Range of Olefins.

ABSTRACT: Reported herein is a new iron-catalyzed diastereoselective olefin diazidation reaction which occurs at room temperature (1-5?mol% of catalysts and d.r.?values of up to >20:1). This method tolerates a broad range of both unfunctionalized and highly functionalized olefins, including those that are incompatible with existing methods. It also provides a convenient approach to vicinal primary diamines as well as other synthetically valuable nitrogen-containing building blocks which are difficult to obtain with alternative methods. Preliminary mechanistic studies suggest that the reaction may proceed through a new mechanistic pathway in which both Lewis acid activation and iron-enabled redox-catalysis are crucial for selective azido-group transfer.

SUBMITTER: Yuan YA

PROVIDER: S-EPMC4719780 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Iron-Catalyzed Direct Diazidation for a Broad Range of Olefins.

Yuan Yong-An YA Lu Deng-Fu DF Chen Yun-Rong YR Xu Hao H

Angewandte Chemie (International ed. in English) 20151123 2

Reported herein is a new iron-catalyzed diastereoselective olefin diazidation reaction which occurs at room temperature (1-5 mol% of catalysts and d.r. values of up to >20:1). This method tolerates a broad range of both unfunctionalized and highly functionalized olefins, including those that are incompatible with existing methods. It also provides a convenient approach to vicinal primary diamines as well as other synthetically valuable nitrogen-containing building blocks which are difficult to o ...[more]

PMID: 26593039

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