Ontology highlight
ABSTRACT:
SUBMITTER: Roth JM
PROVIDER: S-EPMC4720127 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Roth Judith Marlene JM Köhler David D Schneider Mariella M Granja Tiago Folgosa TF Rosenberger Peter P
PloS one 20160111 1
The extent of pulmonary inflammation during lung injury ultimately determines patient outcome. Pulmonary inflammation is initiated by the migration of neutrophils into the alveolar space. Recent work has demonstrated that the guidance protein semaphorin 7A (SEMA7A) influences the migration of neutrophils into hypoxic tissue sites, yet, its role during lung injury is not well understood. Here, we report that the expression of SEMA7A is induced in vitro through pro-inflammatory cytokines. SEMA7A i ...[more]