A tug-of-war between the host and the pathogen generates strategic hotspots for the development of novel therapeutic interventions against infectious diseases.
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ABSTRACT:
SUBMITTER: Rana A
PROVIDER: S-EPMC4720223 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
A tug-of-war between the host and the pathogen generates strategic hotspots for the development of novel therapeutic interventions against infectious diseases.
Rana Aarti A Ahmed Mushtaq M Rub Abdur A Akhter Yusuf Y
Virulence 20150624 6
Microbial pathogens are known to express an array of specific signaling molecules referred as Pathogen Associated Molecular Patterns (PAMPs), which are recognized by Pattern Recognition Receptors (PRRs), present on the surface of the host cells. Interactions between PAMPs and PRRs on the surface of the host cells lead to signaling events which could culminate into either successful infection or clearance of the pathogens. Here, we summarize how these events may generate novel host based as well ...[more]
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