Functional characterization of the antibiotic resistance reservoir in the human microflora.
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ABSTRACT:
SUBMITTER: Sommer MOA
PROVIDER: S-EPMC4720503 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Functional characterization of the antibiotic resistance reservoir in the human microflora.
Sommer Morten O A MOA Dantas Gautam G Church George M GM
Science (New York, N.Y.) 20090801 5944
To understand the process by which antibiotic resistance genes are acquired by human pathogens, we functionally characterized the resistance reservoir in the microbial flora of healthy individuals. Most of the resistance genes we identified using culture-independent sampling have not been previously identified and are evolutionarily distant from known resistance genes. By contrast, nearly half of the resistance genes we identified in cultured aerobic gut isolates (a small subset of the gut micro ...[more]
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