Ontology highlight
ABSTRACT:
SUBMITTER: Cieslak JA
PROVIDER: S-EPMC4720529 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Cieslak John A JA Sibenaller Zita A ZA Walsh Susan A SA Ponto Laura L Boles LL Du Juan J Sunderland John J JJ Cullen Joseph J JJ
Radiation research 20151231 1
Pharmacological ascorbate (AscH(-)) induces cytotoxicity and oxidative stress selectively in pancreatic cancer cells compared with normal cells. Positron emission tomography (PET) with the thymidine analog 3'-deoxy-3'-((18)F) fluorothymidine (FLT) enables noninvasive imaging and quantification of the proliferation fraction of tumors. We hypothesized that the rate of tumor proliferation determined by FLT-PET imaging, would be inversely proportional to tumor susceptibility to pharmacological AscH( ...[more]