Practical designs for Phase I combination studies in oncology.
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ABSTRACT:
SUBMITTER: Wages NA
PROVIDER: S-EPMC4720553 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Practical designs for Phase I combination studies in oncology.
Wages Nolan A NA Ivanova Anastasia A Marchenko Olga O
Journal of biopharmaceutical statistics 20160101 1
Phase I trials evaluating the safety of multidrug combinations are becoming more common in oncology. Despite the emergence of novel methodology in the area, it is rare that innovative approaches are used in practice. In this article, we review three methods for Phase I combination studies that are easy to understand and straightforward to implement. We demonstrate the operating characteristics of the designs through illustration in a single trial, as well as through extensive simulation studies, ...[more]
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