Ontology highlight
ABSTRACT:
SUBMITTER: Hirakawa A
PROVIDER: S-EPMC4806394 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Hirakawa Akihiro A Wages Nolan A NA Sato Hiroyuki H Matsui Shigeyuki S
Statistics in medicine 20150513 24
Little is known about the relative performance of competing model-based dose-finding methods for combination phase I trials. In this study, we focused on five model-based dose-finding methods that have been recently developed. We compared the recommendation rates for true maximum-tolerated dose combinations (MTDCs) and over-dose combinations among these methods under 16 scenarios for 3 × 3, 4 × 4, 2 × 4, and 3 × 5 dose combination matrices. We found that performance of the model-based dose-findi ...[more]