Ontology highlight
ABSTRACT:
SUBMITTER: Kanno T
PROVIDER: S-EPMC4720983 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20141110 12
Small-molecule BET inhibitors interfere with the epigenetic interactions between acetylated histones and the bromodomains of the BET family proteins, including BRD4, and they potently inhibit growth of malignant cells by targeting cancer-promoting genes. BRD4 interacts with the pause-release factor P-TEFb and has been proposed to release RNA polymerase II (Pol II) from promoter-proximal pausing. We show that BRD4 occupies widespread genomic regions in mouse cells and directly stimulates elongati ...[more]