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Persistent HIV Type 1 Seronegative Status Is Associated With Lower CD8+ T-Cell Activation.

ABSTRACT: We leveraged data from the Preexposure Prophylaxis Initiative (iPrEx), a global trial of preexposure chemoprophylaxis against human immunodeficiency virus type 1 (HIV-1) infection, to compare T-cell activation between those who remained negative for HIV-1 and those who became infected during the trial. The frequency of CD38(+)HLA-DR(+) CD8(+) T cells was greater in those who seroconverted, relative to the frequency in those who remained uninfected (1.30% vs 0.82%, respectively; P = .005). This translated to an odds ratio of 4.26 (95% confidence interval, 1.54-11.78) for the association between CD8(+) T-cell activation and infection with HIV-1. T-cell activation may be a biomarker for elevated HIV-1 infection risk.

SUBMITTER: Kuebler PJ

PROVIDER: S-EPMC4721903 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Persistent HIV Type 1 Seronegative Status Is Associated With Lower CD8+ T-Cell Activation.

Kuebler Peter J PJ Mehrotra Megha L ML Shaw Brian I BI Leadabrand Kaitlyn S KS Milush Jeffrey M JM York Vanessa A VA Defechereux Patricia P Grant Robert M RM Kallás Esper G EG Nixon Douglas F DF

The Journal of infectious diseases 20150826 4

We leveraged data from the Preexposure Prophylaxis Initiative (iPrEx), a global trial of preexposure chemoprophylaxis against human immunodeficiency virus type 1 (HIV-1) infection, to compare T-cell activation between those who remained negative for HIV-1 and those who became infected during the trial. The frequency of CD38(+)HLA-DR(+) CD8(+) T cells was greater in those who seroconverted, relative to the frequency in those who remained uninfected (1.30% vs 0.82%, respectively; P = .005). This t ...[more]

PMID: 26310308

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