Ontology highlight
ABSTRACT:
SUBMITTER: Giovannoni MP
PROVIDER: S-EPMC4721940 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Journal of enzyme inhibition and medicinal chemistry 20150721 4
Compounds that can effectively inhibit the proteolytic activity of human neutrophil elastase (HNE) represent promising therapeutics for treatment of inflammatory diseases. We present here the synthesis, structure-activity relationship analysis, and biological evaluation of a new series of HNE inhibitors with a cinnoline scaffold. These compounds exhibited HNE inhibitory activity but had lower potency compared to N-benzoylindazoles previously reported by us. On the other hand, they exhibited incr ...[more]