Ontology highlight
ABSTRACT:
SUBMITTER: Yu M
PROVIDER: S-EPMC4722972 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Yu Mu M Liu San-ling SL Sun Pei-bei PB Pan Hao H Tian Chang-lin CL Zhang Long-hua LH
Acta pharmacologica Sinica 20160101 1
Large conductance, Ca(2+)-activated potassium (BK) channels play important roles in the regulation of neuronal excitability and the control of smooth muscle contractions. BK channels can be activated by changes in both the membrane potential and intracellular Ca(2+) concentrations. Here, we provide an overview of the structural and pharmacological properties of BK channel blockers. First, the properties of different venom peptide toxins from scorpions and snakes are described, with a focus on th ...[more]