Ontology highlight
ABSTRACT:
SUBMITTER: Boac BM
PROVIDER: S-EPMC4724442 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Boac Bernadette M BM Xiong Yin Y Marchion Douglas C DC Abbasi Forough F Bush Stephen H SH Ramirez Ingrid J IJ Khulpateea Beman R BR Clair McClung E E Berry Amy L AL Bou Zgheib Nadim N Chon Hye Sook HS Shahzad Mian M MM Judson Patricia L PL Wenham Robert M RM Apte Sachin M SM Berglund Anders E AE Magliocco Anthony M AM Lancaster Johnathan M JM
Gynecologic oncology 20151228 2
<h4>Objectives</h4>Ovarian cancer (OVCA) is the leading cause of mortality among women with gynecologic malignancy, in part due to the development of chemoresistance. We sought to identify micro-RNAs (miRNAs) associated with in vitro development of OVCA chemoresistance that may also represent potential targets for therapy.<h4>Methods</h4>In this study, four OVCA cell lines (A2780CP, A2780S, IGROV1, and OVCAR5) were serially treated with cisplatin in parallel with measurements of miRNA expression ...[more]