Ontology highlight
ABSTRACT:
SUBMITTER: Douglas JJ
PROVIDER: S-EPMC4725294 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20151016 49
A visible-light-mediated radical Smiles rearrangement has been developed to address the challenging synthesis of the gem-difluoro group present in an opioid receptor-like 1 (ORL-1) antagonist that is currently in development for the treatment of depression and/or obesity. This method enables the direct and efficient introduction of the difluoroethanol motif into a range of aryl and heteroaryl systems, representing a new disconnection for the synthesis of this versatile moiety. When applied to th ...[more]