Ontology highlight
ABSTRACT:
SUBMITTER: Pujadas G
PROVIDER: S-EPMC4725895 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Pujadas G G Cervantes S S Tutusaus A A Ejarque M M Sanchez L L García A A Esteban Y Y Fargas L L Alsina B B Hartmann C C Gomis R R Gasa R R
Scientific reports 20160114
Transcriptional and signaling networks establish complex cross-regulatory interactions that drive cellular differentiation during development. Using microarrays we identified the gene encoding the ligand Wnt9a as a candidate target of Neurogenin3, a basic helix-loop-helix transcription factor that functions as a master regulator of pancreatic endocrine differentiation. Here we show that Wnt9a is expressed in the embryonic pancreas and that its deficiency enhances activation of the endocrine tran ...[more]