Ontology highlight
ABSTRACT:
SUBMITTER: Tomlinson JH
PROVIDER: S-EPMC4725979 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Tomlinson Jennifer H JH Thompson Gary S GS Kalverda Arnout P AP Zhuravleva Anastasia A O'Neill Alex J AJ
Scientific reports 20160119
Antibiotic resistance in clinically important bacteria can be mediated by proteins that physically associate with the drug target and act to protect it from the inhibitory effects of an antibiotic. We present here the first detailed structural characterization of such a target protection mechanism mediated through a protein-protein interaction, revealing the architecture of the complex formed between the FusB fusidic acid resistance protein and the drug target (EF-G) it acts to protect. Binding ...[more]