Ontology highlight
ABSTRACT:
SUBMITTER: Wang SB
PROVIDER: S-EPMC4726296 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Wang Shi-Bo SB Feng Jian-Ying JY Ren Wen-Long WL Huang Bo B Zhou Ling L Wen Yang-Jun YJ Zhang Jin J Dunwell Jim M JM Xu Shizhong S Zhang Yuan-Ming YM
Scientific reports 20160120
Genome-wide association studies (GWAS) have been widely used in genetic dissection of complex traits. However, common methods are all based on a fixed-SNP-effect mixed linear model (MLM) and single marker analysis, such as efficient mixed model analysis (EMMA). These methods require Bonferroni correction for multiple tests, which often is too conservative when the number of markers is extremely large. To address this concern, we proposed a random-SNP-effect MLM (RMLM) and a multi-locus RMLM (MRM ...[more]