Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Z
PROVIDER: S-EPMC4726437 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Zhou Zhiwen Z Tanaka Kenji F KF Matsunaga Shigeru S Iseki Mineo M Watanabe Masakatsu M Matsuki Norio N Ikegaya Yuji Y Koyama Ryuta R
Scientific reports 20160122
Spatiotemporal regulation of axonal branching and elongation is essential in the development of refined neural circuits. cAMP is a key regulator of axonal growth; however, whether and how intracellular cAMP regulates axonal branching and elongation remain unclear, mainly because tools to spatiotemporally manipulate intracellular cAMP levels have been lacking. To overcome this issue, we utilized photoactivated adenylyl cyclase (PAC), which produces cAMP in response to blue-light exposure. In prim ...[more]