Ontology highlight
ABSTRACT:
SUBMITTER: Sa Santos S
PROVIDER: S-EPMC4726799 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Sá Santos Sónia S Santos Sara M SM Pinto Antónia R T AR Ramu Vasanthakumar G VG Heras Montserrat M Bardaji Eduard E Tavares Isaura I Castanho Miguel A R B MA
Frontiers in aging neuroscience 20160126
Chronic brain ischemia is a prominent risk factor for neurological dysfunction and progression for dementias, including Alzheimer's disease (AD). In rats, permanent bilateral common carotid artery occlusion (2VO) causes a progressive neurodegeneration in the hippocampus, learning deficits and memory loss as it occurs in AD. Kyotorphin (KTP) is an endogenous antinociceptive dipeptide whose role as neuromodulator/neuroprotector has been suggested. Recently, we designed two analgesic KTP-derivative ...[more]