Ontology highlight
ABSTRACT:
SUBMITTER: Guo C
PROVIDER: S-EPMC4726870 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Guo Cenqi C Tsigkou Anastasia A Lee Meng Huee MH
Biomedical reports 20151030 1
A disintegrin and metalloproteinase with thombospondin motifs (ADAMTS) 13 and 15 are secreted zinc proteinases involved in the turnover of von Willebrand factor and cancer suppression. In the present study, ADAMTS13 and 15 were subjected to inhibition studies with the full-length and N-terminal domain forms of tissue inhibitor of metalloproteinases (TIMPs)-1 to -4. TIMPs have no ability to inhibit the ADAMTS proteinases in the full-length or N-terminal domain form. While ADAMTS13 is also not sen ...[more]