Dataset Information

Tumor necrosis factor-alpha-induced protein 1 and immunity to hepatitis B virus.

ABSTRACT:

Aim

To compare the gene expression profile in a pair of HBV-infected twins.

Methods

The gene expression profile was compared in a pair of HBV-infected twins.

Results

The twins displayed different disease outcomes. One acquired natural immunity against HBV, whereas the other became a chronic HBV carrier. Eighty-eight and forty-six genes were found to be up- or down-regulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-alphaIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RT-PCR. However, upon HBV core antigen stimulation, TNF-alphaIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+ channel tetramerization domain in TNF-alphaIP1 that shares a significant homology with some human, mouse, and C elegan proteins.

Conclusion

TNF-alphaIP1 may play a role in the innate immunity against HBV.

SUBMITTER: Lin MC

PROVIDER: S-EPMC4727213 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature

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Publications

Tumor necrosis factor-alpha-induced protein 1 and immunity to hepatitis B virus.

Lin Marie C MC Lee Nikki P NP Zheng Ning N Yang Pai-Hao PH Wong Oscar G OG Kung Hsiang-Fu HF Hui Chee-Kin CK Luk John M JM Lau George Ka-Kit GK

World journal of gastroenterology 20051201 48

<h4>Aim</h4>To compare the gene expression profile in a pair of HBV-infected twins.<h4>Methods</h4>The gene expression profile was compared in a pair of HBV-infected twins.<h4>Results</h4>The twins displayed different disease outcomes. One acquired natural immunity against HBV, whereas the other became a chronic HBV carrier. Eighty-eight and forty-six genes were found to be up- or down-regulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-alphaIP1) that expre ...[more]

PMID: 16437679

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Dataset Information

Tumor necrosis factor-alpha-induced protein 1 and immunity to hepatitis B virus.

Aim

Methods

Results

Conclusion

Publications

Tumor necrosis factor-alpha-induced protein 1 and immunity to hepatitis B virus.

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