Gemcitabine and Chlorotoxin Conjugated Iron Oxide Nanoparticles for Glioblastoma Therapy.
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ABSTRACT:
SUBMITTER: Mu Q
PROVIDER: S-EPMC4727823 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Gemcitabine and Chlorotoxin Conjugated Iron Oxide Nanoparticles for Glioblastoma Therapy.
Mu Qingxin Q Lin Guanyou G Patton Victoria K VK Wang Kui K Press Oliver W OW Zhang Miqin M
Journal of materials chemistry. B 20151124 1
Many small-molecule anti-cancer drugs have short blood half-lives and toxicity issues due to non-specificity. Nanotechnology has shown great promise in addressing these issues. Here, we report the development of an anti-cancer drug gemcitabine-conjugated iron oxide nanoparticle for glioblastoma therapy. A glioblastoma targeting peptide, chlorotoxin, was attached after drug conjugation. The nanoparticle has a small size (~32 nm) and uniform size distribution (PDI ≈ 0.1), and is stable in biologic ...[more]
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