Ontology highlight
ABSTRACT:
SUBMITTER: Dubrac A
PROVIDER: S-EPMC4729599 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Dubrac Alexandre A Genet Gael G Ola Roxana R Zhang Feng F Pibouin-Fragner Laurence L Han Jinah J Zhang Jiasheng J Thomas Jean-Léon JL Chedotal Alain A Schwartz Martin A MA Eichmann Anne A
Circulation 20151209 4
<h4>Background</h4>Sprouting angiogenesis is a key process driving blood vessel growth in ischemic tissues and an important drug target in a number of diseases, including wet macular degeneration and wound healing. Endothelial cells forming the sprout must develop front-rear polarity to allow sprout extension. The adaptor proteins Nck1 and 2 are known regulators of cytoskeletal dynamics and polarity, but their function in angiogenesis is poorly understood. Here, we show that the Nck adaptors are ...[more]