Ontology highlight
ABSTRACT:
SUBMITTER: Su S
PROVIDER: S-EPMC4730182 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Su Shu S Hu Bian B Shao Jie J Shen Bin B Du Juan J Du Yinan Y Zhou Jiankui J Yu Lixia L Zhang Lianru L Chen Fangjun F Sha Huizi H Cheng Lei L Meng Fanyan F Zou Zhengyun Z Huang Xingxu X Liu Baorui B
Scientific reports 20160128
Strategies that enhance the function of T cells are critical for immunotherapy. One negative regulator of T-cell activity is ligand PD-L1, which is expressed on dentritic cells (DCs) or some tumor cells, and functions through binding of programmed death-1 (PD-1) receptor on activated T cells. Here we described for the first time a non-viral mediated approach to reprogram primary human T cells by disruption of PD-1. We showed that the gene knockout of PD-1 by electroporation of plasmids encoding ...[more]