Ontology highlight
ABSTRACT:
SUBMITTER: da Costa-Silva TA
PROVIDER: S-EPMC4730870 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
da Costa-Silva Thais Alves TA Grecco Simone S SS de Sousa Fernanda S FS Lago João Henrique G JH Martins Euder G A EG Terrazas César A CA Varikuti Sanjay S Owens Katherine L KL Beverley Stephen M SM Satoskar Abhay R AR Tempone Andre G AG Tempone Andre G AG
Journal of natural products 20150402 4
Three phenylpropanoid dimers (1-3) including two new metabolites were isolated from the extract of the twigs of Nectandra leucantha using antileishmanial bioassay-guided fractionation. The in vitro antiparasitic activity of the isolated compounds against Leishmania donovani parasites and mammalian cytotoxicity and immunomodulatory effects were evaluated. Compounds 1-3 were effective against the intracellular amastigotes within macrophages, with IC50 values of 26.7, 17.8, and 101.9 μM, respective ...[more]