Unknown

Dataset Information

0

Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles.

ABSTRACT: A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as regioisomeric mixtures that were separated by column chromatography and fully characterized. Most of the compounds displayed antiparasitic activity against Trypanosoma cruzi and Leishmania donovani. The most active compounds were assayed as potential TcCYP51 inhibitors.

SUBMITTER: Porta EOJ 

PROVIDER: S-EPMC5629980 | biostudies-literature |

REPOSITORIES: biostudies-literature

Json Xml

Similar Datasets

Unknown Antitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones from Polygonum salicifolium.
| S-EPMC7915666 | biostudies-literature
Unknown Synthesis of deuterated 1,2,3-triazoles.
| S-EPMC3543115 | biostudies-literature
Unknown Efficient synthesis of 1-sulfonyl-1,2,3-triazoles.
| S-EPMC2982995 | biostudies-literature
Unknown Tandem synthesis of 1-formyl-1,2,3-triazoles.
| S-EPMC5798646 | biostudies-literature
Unknown Direct Pd-catalyzed arylation of 1,2,3-triazoles.
| S-EPMC3689219 | biostudies-literature
Unknown A Comprehensive QSAR Study on Antileishmanial and Antitrypanosomal Cinnamate Ester Analogues.
| S-EPMC6930487 | biostudies-literature
Unknown Reactivity of N-(1,2,4-triazolyl)-substituted 1,2,3-triazoles.
| S-EPMC3224851 | biostudies-literature
Unknown Transannulation of 1-sulfonyl-1,2,3-triazoles with heterocumulenes.
| S-EPMC3645925 | biostudies-literature
Unknown Rhodium-catalyzed transannulation of 1,2,3-triazoles with nitriles.
| S-EPMC2668606 | biostudies-literature
Unknown Catalytic asymmetric transannulation of NH-1,2,3-triazoles with olefins.
| S-EPMC4082713 | biostudies-literature