Ontology highlight
ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC4731190 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Yu Jian J Chen Liguang L Cui Bing B Widhopf George F GF Shen Zhouxin Z Wu Rongrong R Zhang Ling L Zhang Suping S Briggs Steven P SP Kipps Thomas J TJ
The Journal of clinical investigation 20160201 2
Evolutionarily conserved receptor tyrosine kinase–like orphan receptor-1 and -2 (ROR1/2) are considered distinct receptors for Wnt5a and are implicated in noncanonical Wnt signaling in organogenesis and cancer metastasis. We found that Wnt5a enhanced proliferation and migration of chronic lymphocytic leukemia (CLL) cells and that these effects were blocked by the humanized anti-ROR1 mAb cirmtuzumab (UC-961). Treatment of CLL cells with Wnt5a induced ROR1 to oligomerize with ROR2 and recruit guan ...[more]