Ontology highlight
ABSTRACT:
SUBMITTER: Krueger AS
PROVIDER: S-EPMC4731467 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
PloS one 20160128 1
Flux balance analysis (FBA) is an increasingly useful approach for modeling the behavior of metabolic systems. However, standard FBA modeling of genetic knockouts cannot predict drug combination synergies observed between serial metabolic targets, even though such synergies give rise to some of the most widely used antibiotic treatments. Here we extend FBA modeling to simulate responses to chemical inhibitors at varying concentrations, by diverting enzymatic flux to a waste reaction. This flux d ...[more]