Ontology highlight
ABSTRACT:
SUBMITTER: Doyon N
PROVIDER: S-EPMC4731508 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Doyon Nicolas N Prescott Steven A SA De Koninck Yves Y
Frontiers in cellular neuroscience 20160129
Disinhibition caused by Cl(-) dysregulation is implicated in several neurological disorders. This form of disinhibition, which stems primarily from impaired Cl(-) extrusion through the co-transporter KCC2, is typically identified by a depolarizing shift in GABA reversal potential (E GABA). Here we show, using computer simulations, that intracellular [Cl(-)] exhibits exaggerated fluctuations during transient Cl(-) loads and recovers more slowly to baseline when KCC2 level is even modestly reduced ...[more]