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MGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia.

ABSTRACT: Multiple lines of evidence point to glutamatergic signaling in the postsynaptic density (PSD) as a pathophysiologic mechanism in schizophrenia. Integral to PSD glutamatergic signaling is reciprocal interplay between GluN and mGluR5 signaling. We examined agonist-induced mGluR5 signaling in the postmortem dorsolateral prefrontal cortex (DLPFC) derived from 17 patients and age-matched and sex-matched controls. The patient group showed a striking reduction in mGluR5 signaling, manifested by decreases in Gq/11 coupling and association with PI3K and Homer compared to controls (p?

SUBMITTER: Wang HY

PROVIDER: S-EPMC7500805 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia.

Wang Hoau-Yan HY MacDonald Mathew L ML Borgmann-Winter Karin E KE Banerjee Anamika A Sleiman Patrick P Tom Andrew A Khan Amber A Lee Kuo-Chieh KC Roussos Panos P Siegel Steven J SJ Hemby Scott E SE Bilker Warren B WB Gur Raquel E RE Hahn Chang-Gyu CG

Molecular psychiatry 20180913 4

Multiple lines of evidence point to glutamatergic signaling in the postsynaptic density (PSD) as a pathophysiologic mechanism in schizophrenia. Integral to PSD glutamatergic signaling is reciprocal interplay between GluN and mGluR5 signaling. We examined agonist-induced mGluR5 signaling in the postmortem dorsolateral prefrontal cortex (DLPFC) derived from 17 patients and age-matched and sex-matched controls. The patient group showed a striking reduction in mGluR5 signaling, manifested by decreas ...[more]

PMID: 30214040

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