MGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia.
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ABSTRACT:
SUBMITTER: Wang HY
PROVIDER: S-EPMC7500805 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia.
Wang Hoau-Yan HY MacDonald Mathew L ML Borgmann-Winter Karin E KE Banerjee Anamika A Sleiman Patrick P Tom Andrew A Khan Amber A Lee Kuo-Chieh KC Roussos Panos P Siegel Steven J SJ Hemby Scott E SE Bilker Warren B WB Gur Raquel E RE Hahn Chang-Gyu CG
Molecular psychiatry 20180913 4
Multiple lines of evidence point to glutamatergic signaling in the postsynaptic density (PSD) as a pathophysiologic mechanism in schizophrenia. Integral to PSD glutamatergic signaling is reciprocal interplay between GluN and mGluR5 signaling. We examined agonist-induced mGluR5 signaling in the postmortem dorsolateral prefrontal cortex (DLPFC) derived from 17 patients and age-matched and sex-matched controls. The patient group showed a striking reduction in mGluR5 signaling, manifested by decreas ...[more]
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