Ontology highlight
ABSTRACT:
SUBMITTER: de Taeye SW
PROVIDER: S-EPMC4732737 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Cell 20151201 7
The envelope glycoprotein trimer mediates HIV-1 entry into cells. The trimer is flexible, fluctuating between closed and more open conformations and sometimes sampling the fully open, CD4-bound form. We hypothesized that conformational flexibility and transient exposure of non-neutralizing, immunodominant epitopes could hinder the induction of broadly neutralizing antibodies (bNAbs). We therefore modified soluble Env trimers to stabilize their closed, ground states. The trimer variants were inde ...[more]