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Structure of an HIV-2 gp120 in Complex with CD4.

ABSTRACT: HIV-2 is a nonpandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term nonprogression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30 to 40% identity. As a first step in understanding the reduced pathogenicity of HIV-2, we solved a 3.0-Å structure of an HIV-2 gp120 bound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence in amino acid sequence.

SUBMITTER: Davenport YW

PROVIDER: S-EPMC4733984 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Structure of an HIV-2 gp120 in Complex with CD4.

Davenport Yunji W YW West Anthony P AP Bjorkman Pamela J PJ

Journal of virology 20151125 4

HIV-2 is a nonpandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term nonprogression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30 to 40% identity. As a first step in understanding the reduced pathogenicity of HIV-2, we solved a 3.0-Å structure of an HIV-2 gp120 bound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence in amino acid sequence. ...[more]

PMID: 26608312

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