Ontology highlight
ABSTRACT:
SUBMITTER: Duan LW
PROVIDER: S-EPMC5399459 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Duan Liang-Wei LW Zhang Hui H Zhao Meng-Ting MT Sun Ji-Xue JX Chen Wen-Li WL Lin Jian-Ping JP Liu Xin-Qi XQ
Scientific reports 20170421
Numerous crystal structures of HIV gp120 have been reported, alone or with receptor CD4 and cognate antibodies; however, no sole gp120/CD4 complex without stabilization by an antibody is available. Here, we report a crystal structure of the gp120/CD4 complex without the aid of an antibody from HIV-1 CRF07_BC, a strain circulating in China. Interestingly, in addition to the canonical binding surface, a second interacting interface was identified. A mutagenesis study on critical residues revealed ...[more]