Ontology highlight
ABSTRACT:
SUBMITTER: Le-Trilling VT
PROVIDER: S-EPMC4734293 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Le-Trilling Vu Thuy Khanh VT Megger Dominik A DA Katschinski Benjamin B Landsberg Christine D CD Rückborn Meike U MU Tao Sha S Krawczyk Adalbert A Bayer Wibke W Drexler Ingo I Tenbusch Matthias M Sitek Barbara B Trilling Mirko M
Scientific reports 20160201
In terms of infected human individuals, herpesviruses range among the most successful virus families. Subclinical herpesviral infections in healthy individuals contrast with life-threatening syndromes under immunocompromising and immunoimmature conditions. Based on our finding that cytomegaloviruses interact with Cullin Roc ubiquitin ligases (CRLs) in the context of interferon antagonism, we systematically assessed viral dependency on CRLs by utilizing the drug MLN4924. CRL activity is regulated ...[more]