Dataset Information

Expression of TLR-7, MyD88, NF-kB, and INF-? in B Lymphocytes of Mayan Women with Systemic Lupus Erythematosus in Mexico.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease involving multiple organs. It is currently accepted that several genetic, environmental, and hormonal factors are contributing to its development. Innate immunity may have a great influence in autoimmunity through Toll-like receptors. TLR-7 recognizing single-strand RNA has been involved in SLE. Its activation induces intracellular signal with attraction of MyD88 and NF-kBp65, leading to IFN-? synthesis which correlate with disease activity.

Objective

To assess the expression of TLR-7, MyD88, and NF-kBp65 in B lymphocytes of Mayan women with SLE.

Methods

One hundred patients with SLE and 100 healthy controls, all of them Mayan women, were included. TLR-7 was analyzed on B and T lymphocytes, and MyD88 and NF-kB only in B lymphocytes. Serum INF-? level was evaluated by ELISA.

Results

Significant expression (p?ConclusionData support the role of TLR-7 and signal proteins in the pathogenesis of SLE in the Mayan population of Yucatán.

SUBMITTER: Pacheco GV

PROVIDER: S-EPMC4735402 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Expression of TLR-7, MyD88, NF-kB, and INF-α in B Lymphocytes of Mayan Women with Systemic Lupus Erythematosus in Mexico.

Pacheco Guillermo Valencia GV Novelo Noh Irene B IB Velasco Cárdenas Rubí M-H RM Angulo Ramírez Angélica V AV López Villanueva Ricardo F RF Quintal Ortiz Irma G IG Alonso Salomón Ligia G LG Ruz Norma Pavía NP Rivero Cárdenas Nubia A NA

Frontiers in immunology 20160202

<h4>Background</h4>Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease involving multiple organs. It is currently accepted that several genetic, environmental, and hormonal factors are contributing to its development. Innate immunity may have a great influence in autoimmunity through Toll-like receptors. TLR-7 recognizing single-strand RNA has been involved in SLE. Its activation induces intracellular signal with attraction of MyD88 and NF-kBp65, leading to IFN-α synt ...[more]

PMID: 26870038

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