Ontology highlight
ABSTRACT:
SUBMITTER: Couderc C
PROVIDER: S-EPMC4735628 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Couderc Christophe C Boin Alizée A Fuhrmann Laetitia L Vincent-Salomon Anne A Mandati Vinay V Kieffer Yann Y Mechta-Grigoriou Fatima F Del Maestro Laurence L Chavrier Philippe P Vallerand David D Brito Isabelle I Dubois Thierry T De Koning Leanne L Bouvard Daniel D Louvard Daniel D Gautreau Alexis A Lallemand Dominique D
Neoplasia (New York, N.Y.) 20160101 1
The Hippo signaling network is a key regulator of cell fate. In the recent years, it was shown that its implication in cancer goes well beyond the sole role of YAP transcriptional activity and its regulation by the canonical MST/LATS kinase cascade. Here we show that the motin family member AMOTL1 is an important effector of Hippo signaling in breast cancer. AMOTL1 connects Hippo signaling to tumor cell aggressiveness. We show that both canonical and noncanonical Hippo signaling modulates AMOTL1 ...[more]