Ontology highlight
ABSTRACT:
SUBMITTER: Cho SM
PROVIDER: S-EPMC4735736 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20160202
Amyloid-β (Aβ) plays a critical role as a biomarker in Alzheimer's disease (AD) diagnosis. In addition to its diagnostic potential in the brain, recent studies have suggested that changes of Aβ level in the plasma can possibly indicate AD onset. In this study, we found that plasma Aβ(1-42) concentration increases with age, while the concentration of Aβ(1-42) in the cerebrospinal fluid (CSF) decreases in APPswe, PS1M146V and TauP301L transgenic (3xTg-AD) mice, if measurements were made before for ...[more]