Ontology highlight
ABSTRACT:
SUBMITTER: Cho SM
PROVIDER: S-EPMC4735736 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Cho Soo Min SM Lee Sejin S Yang Seung-Hoon SH Kim Hye Yun HY Lee Michael Jisoo MJ Kim Hyunjin Vincent HV Kim Jiyoon J Baek Seungyeop S Yun Jin J Kim Dohee D Kim Yun Kyung YK Cho Yakdol Y Woo Jiwan J Kim Tae Song TS Kim YoungSoo Y
Scientific reports 20160202
Amyloid-β (Aβ) plays a critical role as a biomarker in Alzheimer's disease (AD) diagnosis. In addition to its diagnostic potential in the brain, recent studies have suggested that changes of Aβ level in the plasma can possibly indicate AD onset. In this study, we found that plasma Aβ(1-42) concentration increases with age, while the concentration of Aβ(1-42) in the cerebrospinal fluid (CSF) decreases in APPswe, PS1M146V and TauP301L transgenic (3xTg-AD) mice, if measurements were made before for ...[more]