Ontology highlight
ABSTRACT:
SUBMITTER: Cruchaga C
PROVIDER: S-EPMC3979575 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Current genetic medicine reports 20140301 1
The use of cerebrospinal fluid levels of Aβ42 and pTau181 as endophenotypes for genetic studies of Alzheimer's disease (AD) has led to successful identification of both rare and common AD risk variants. In addition, this approach has provided meaningful hypotheses for the biological mechanisms by which known AD risk variants modulate the disease process. In this article we discuss these successes and outline challenges to effective and continued applications of this approach. We contrast the sta ...[more]