Ontology highlight
ABSTRACT:
SUBMITTER: Kim YS
PROVIDER: S-EPMC4735737 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Kim Yeon Sun YS Kim Hye-Ryun HR Kim Hyongbum H Yang Seung Chel SC Park Mira M Yoon Jung Ah JA Lim Hyunjung J HJ Hong Seok-Ho SH DeMayo Francesco J FJ Lydon John P JP Choi Youngsok Y Lee Dong Ryul DR Song Haengseok H
Scientific reports 20160202
DGCR8 is an RNA-binding protein that interacts with DROSHA to produce pre-microRNA in the nucleus, while DICER generates not only mature microRNA, but also endogenous small interfering RNAs in the cytoplasm. Here, we produced Dgcr8 conditional knock-out mice using progesterone receptor (PR)-Cre (Dgcr8(d/d)) and demonstrated that canonical microRNAs dependent on the DROSHA-DGCR8 complex are required for uterine development as well as female fertility in mice. Adult Dgcr8(d/d) females neither unde ...[more]