Ontology highlight
ABSTRACT:
SUBMITTER: Ai X
PROVIDER: S-EPMC4736106 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Ai Xiangzhao X Ho Chris Jun Hui CJ Aw Junxin J Attia Amalina Binte Ebrahim AB Mu Jing J Wang Yu Y Wang Xiaoyong X Wang Yong Y Liu Xiaogang X Chen Huabing H Gao Mingyuan M Chen Xiaoyuan X Yeow Edwin K L EK Liu Gang G Olivo Malini M Xing Bengang B
Nature communications 20160120
The development of precision nanomedicines to direct nanostructure-based reagents into tumour-targeted areas remains a critical challenge in clinics. Chemical reaction-mediated localization in response to tumour environmental perturbations offers promising opportunities for rational design of effective nano-theranostics. Here, we present a unique microenvironment-sensitive strategy for localization of peptide-premodified upconversion nanocrystals (UCNs) within tumour areas. Upon tumour-specific ...[more]