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Enantioselective diamination with novel chiral hypervalent iodine catalysts.

ABSTRACT: Vicinal diamines constitute one the most important functional motif in organic chemistry because of its wide occurrence in a variety of biological and pharmaceutical molecules. We report an efficient metal-free, highly stereoselective intramolecular diamination using a novel chiral hypervalent iodine reagent together with its application as an efficient catalyst for the synthesis of diamines.

SUBMITTER: Mizar P

PROVIDER: S-EPMC4736455 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Enantioselective diamination with novel chiral hypervalent iodine catalysts.

Mizar Pushpak P Laverny Aragorn A El-Sherbini Mohammad M Farid Umar U Brown Michael M Malmedy Florence F Wirth Thomas T

Chemistry (Weinheim an der Bergstrasse, Germany) 20140717 32

Vicinal diamines constitute one the most important functional motif in organic chemistry because of its wide occurrence in a variety of biological and pharmaceutical molecules. We report an efficient metal-free, highly stereoselective intramolecular diamination using a novel chiral hypervalent iodine reagent together with its application as an efficient catalyst for the synthesis of diamines. ...[more]

PMID: 25042733

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