Ontology highlight
ABSTRACT:
SUBMITTER: Fodil N
PROVIDER: S-EPMC4738049 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Fodil Nassima N Langlais David D Gros Philippe P
Trends in immunology 20160112 2
Recent advances in genome analysis have provided important insights into the genetic architecture of infectious and inflammatory diseases. The combined analysis of loci detected by genome-wide association studies (GWAS) in 22 inflammatory diseases has revealed a shared genetic core and associated biochemical pathways that play a central role in pathological inflammation. Parallel whole-exome sequencing studies have identified 265 genes mutated in primary immunodeficiencies (PID). Here, we examin ...[more]