Ontology highlight
ABSTRACT:
SUBMITTER: Furukawa Y
PROVIDER: S-EPMC4738331 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20160203
TAR DNA-binding protein 43 (TDP-43) is a DNA/RNA-binding protein containing two consecutive RNA recognition motifs (RRM1 and RRM2) in tandem. Functional abnormality of TDP-43 has been proposed to cause neurodegeneration, but it remains obscure how the physiological functions of this protein are regulated. Here, we show distinct roles of RRM1 and RRM2 in the sequence-specific substrate recognition of TDP-43. RRM1 was found to bind a wide spectrum of ssDNA sequences, while no binding was observed ...[more]