Ontology highlight
ABSTRACT:
SUBMITTER: Mulay SR
PROVIDER: S-EPMC4738349 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Mulay Shrikant R SR Desai Jyaysi J Kumar Santhosh V SV Eberhard Jonathan N JN Thomasova Dana D Romoli Simone S Grigorescu Melissa M Kulkarni Onkar P OP Popper Bastian B Vielhauer Volker V Zuchtriegel Gabriele G Reichel Christoph C Bräsen Jan Hinrich JH Romagnani Paola P Bilyy Rostyslav R Munoz Luis E LE Herrmann Martin M Liapis Helen H Krautwald Stefan S Linkermann Andreas A Anders Hans-Joachim HJ
Nature communications 20160128
Crystals cause injury in numerous disorders, and induce inflammation via the NLRP3 inflammasome, however, it remains unclear how crystals induce cell death. Here we report that crystals of calcium oxalate, monosodium urate, calcium pyrophosphate dihydrate and cystine trigger caspase-independent cell death in five different cell types, which is blocked by necrostatin-1. RNA interference for receptor-interacting protein kinase 3 (RIPK3) or mixed lineage kinase domain like (MLKL), two core proteins ...[more]