Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez DA
PROVIDER: S-EPMC4815980 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Rodriguez D A DA Weinlich R R Brown S S Guy C C Fitzgerald P P Dillon C P CP Oberst A A Quarato G G Low J J Cripps J G JG Chen T T Green D R DR
Cell death and differentiation 20150529 1
Mixed lineage kinase domain-like pseudokinase (MLKL) mediates necroptosis by translocating to the plasma membrane and inducing its rupture. The activation of MLKL occurs in a multimolecular complex (the 'necrosome'), which is comprised of MLKL, receptor-interacting serine/threonine kinase (RIPK)-3 (RIPK3) and, in some cases, RIPK1. Within this complex, RIPK3 phosphorylates the activation loop of MLKL, promoting conformational changes and allowing the formation of MLKL oligomers, which migrate to ...[more]