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Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.


ABSTRACT: Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.

SUBMITTER: Imamura M 

PROVIDER: S-EPMC4738362 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.

Imamura Minako M   Takahashi Atsushi A   Yamauchi Toshimasa T   Hara Kazuo K   Yasuda Kazuki K   Grarup Niels N   Zhao Wei W   Wang Xu X   Huerta-Chagoya Alicia A   Hu Cheng C   Moon Sanghoon S   Long Jirong J   Kwak Soo Heon SH   Rasheed Asif A   Saxena Richa R   Ma Ronald C W RC   Okada Yukinori Y   Iwata Minoru M   Hosoe Jun J   Shojima Nobuhiro N   Iwasaki Minaka M   Fujita Hayato H   Suzuki Ken K   Danesh John J   Jørgensen Torben T   Jørgensen Marit E ME   Witte Daniel R DR   Brandslund Ivan I   Christensen Cramer C   Hansen Torben T   Mercader Josep M JM   Flannick Jason J   Moreno-Macías Hortensia H   Burtt Noël P NP   Zhang Rong R   Kim Young Jin YJ   Zheng Wei W   Singh Jai Rup JR   Tam Claudia H T CH   Hirose Hiroshi H   Maegawa Hiroshi H   Ito Chikako C   Kaku Kohei K   Watada Hirotaka H   Tanaka Yasushi Y   Tobe Kazuyuki K   Kawamori Ryuzo R   Kubo Michiaki M   Cho Yoon Shin YS   Chan Juliana C N JC   Sanghera Dharambir D   Frossard Philippe P   Park Kyong Soo KS   Shu Xiao-Ou XO   Kim Bong-Jo BJ   Florez Jose C JC   Tusié-Luna Teresa T   Jia Weiping W   Tai E Shyong ES   Pedersen Oluf O   Saleheen Danish D   Maeda Shiro S   Kadowaki Takashi T  

Nature communications 20160128


Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA  ...[more]

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