Ontology highlight
ABSTRACT:
SUBMITTER: Nakashima R
PROVIDER: S-EPMC4738370 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Nakashima Ryutaro R Morooka Mayu M Shiraki Nobuaki N Sakano Daisuke D Ogaki Soichiro S Kume Kazuhiko K Kume Shoen S
Genes to cells : devoted to molecular & cellular mechanisms 20151030 12
Pancreatic endocrine β-cells derived from embryonic stem (ES) cells and induced pluripotent stem (iPS) cells have received attention as screening systems for therapeutic drugs and as the basis for cell-based therapies. Here, we used a 12-day β-cell differentiation protocol for mouse ES cells and obtained several hit compounds that promoted β-cell differentiation. One of these compounds, mycophenolic acid (MPA), effectively promoted ES cell differentiation with a concomitant reduction of neuronal ...[more]