Ontology highlight
ABSTRACT:
SUBMITTER: Choi HW
PROVIDER: S-EPMC5283667 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Choi Hyun Woo HW Hong Yean Ju YJ Kim Jong Soo JS Song Hyuk H Cho Ssang Gu SG Bae Hojae H Kim Changsung C Byun Sung June SJ Do Jeong Tae JT
PloS one 20170131 1
Like embryonic stem cells, induced pluripotent stem cells (iPSCs) can differentiate into all three germ layers in an in vitro system. Here, we developed a new technology for obtaining neural stem cells (NSCs) from iPSCs through chimera formation, in an in vivo environment. iPSCs contributed to the neural lineage in the chimera, which could be efficiently purified and directly cultured as NSCs in vitro. The iPSC-derived, in vivo-differentiated NSCs expressed NSC markers, and their gene-expression ...[more]