Ontology highlight
ABSTRACT:
SUBMITTER: Lelli A
PROVIDER: S-EPMC4738386 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Lelli Andrea A Michel Vincent V Boutet de Monvel Jacques J Cortese Matteo M Bosch-Grau Montserrat M Aghaie Asadollah A Perfettini Isabelle I Dupont Typhaine T Avan Paul P El-Amraoui Aziz A Petit Christine C
The Journal of cell biology 20160111 2
The precise architecture of hair bundles, the arrays of mechanosensitive microvilli-like stereocilia crowning the auditory hair cells, is essential to hearing. Myosin IIIa, defective in the late-onset deafness form DFNB30, has been proposed to transport espin-1 to the tips of stereocilia, thereby promoting their elongation. We show that Myo3a(-/-)Myo3b(-/-) mice lacking myosin IIIa and myosin IIIb are profoundly deaf, whereas Myo3a-cKO Myo3b(-/-) mice lacking myosin IIIb and losing myosin IIIa p ...[more]