Ontology highlight
ABSTRACT:
SUBMITTER: Horton ER
PROVIDER: S-EPMC4739608 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Horton Edward R ER Humphries Jonathan D JD Stutchbury Ben B Jacquemet Guillaume G Ballestrem Christoph C Barry Simon T ST Humphries Martin J MJ
The Journal of cell biology 20160201 3
Integrin adhesion complexes (IACs) form mechanochemical connections between the extracellular matrix and actin cytoskeleton and mediate phenotypic responses via posttranslational modifications. Here, we investigate the modularity and robustness of the IAC network to pharmacological perturbation of the key IAC signaling components focal adhesion kinase (FAK) and Src. FAK inhibition using AZ13256675 blocked FAK(Y397) phosphorylation but did not alter IAC composition, as reported by mass spectromet ...[more]