Ontology highlight
ABSTRACT:
SUBMITTER: Stenesen D
PROVIDER: S-EPMC4739767 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Stenesen Drew D Moehlman Andrew T AT Krämer Helmut H
eLife 20151214
Synaptic transmission from Drosophila photoreceptors to lamina neurons requires recycling of histamine neurotransmitter. Synaptic histamine is cleared by uptake into glia and conversion into carcinine, which functions as transport metabolite. How carcinine is transported from glia to photoreceptor neurons remains unclear. In a targeted RNAi screen for genes involved in this pathway, we identified carT, which encodes a member of the SLC22A transporter family. CarT expression in photoreceptors is ...[more]